From the first cannonballs fired by American warships at North African pirates to the conquest of Falluja by the Marines—from the early American explorers who probed the sources of the Nile to the diplomats who strove for Arab-Israeli peace—the United States has been dramatically involved in the Middle East. For well over two centuries, American statesmen, merchants, and missionaries, both men and women, have had a profound impact on the shaping of this crucial region.